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Transgenic HbS Mouse Neutrophils in Increased Susceptibility to Acute Lung Injury*: Implications for Sickle Acute Chest Syndrome

L. Hsu, MD, PhD; T. McDermott; L. Brown; S. M. Aguayo, MD, FCCP
Author and Funding Information

*From Atlanta Veterans Administration Medical Center and Emory University, Atlanta, GA.

Correspondence to: Lewis Hsu, MD, PhD, Emory University School of Medicine, 69 Butler St SE, Atlanta, GA 30303



Chest. 1999;116(suppl_1):92S-93S. doi:10.1378/chest.116.suppl_1.92S
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Extract

The sickle cell acute chest syndrome (ACS) has many clinical similarities to other forms of acute lung injury such as ARDS. We investigated a role for neutrophils in ACS pathophysiology, using a transgenic (Tg) mouse expressing human sickle hemoglobin that has mild features of sickle cell disease under baseline conditions.


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