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Surfactant Lavage Treatment in a Model of Respiratory Distress Syndrome*

Charles G. Cochrane, MD; Susan D. Revak, BA
Author and Funding Information

*From the Department of Immunology, The Scripps Research Institute, La Jolla, CA.

Correspondence to: Charles G. Cochrane, MD, Department of Immunology, IMM12, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037; e-mail: cochrane@scripps.edu



Chest. 1999;116(suppl_1):85S-87S. doi:10.1378/chest.116.suppl_1.85S
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Extract

In a model of ARDS in adult rabbits, we have compared the capacity of exogenous synthetic surfactant, administered by bolus or by lavage, to reexpand the lungs and to inhibit the inflammatory process. The surfactant used contained DPPC and POPG (3:1) together with palmitic acid (15% by weight) and the peptide KLLLLKLLLLKLLLLKLLLLK (KL4) that mimics SP-B.1 This surfactant preparation, termed KL4-surfactant, has been evaluated in animal studies2 and a clinical trial in 47 patients with idiopathic respiratory distress syndrome.3


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