0
Articles |

Signal Transduction by Tumor Necrosis Factor*: The Parker B. Francis Lectureship

David V. Goeddel, PhD
Author and Funding Information

*From Tularik Inc, South San Francisco, CA 94080.

Correspondence to: David V. Goeddel, PhD, Tularik Inc, Two Corporate Dr, South San Francisco, CA 94080; e-mail: goeddel@tularik.com



Chest. 1999;116(suppl_1):69S-73S. doi:10.1378/chest.116.suppl_1.69S
Text Size: A A A
Published online

Extract

Tumor necrosis factor (TNF) is the name of an activity produced by activated macrophages that induced hemorrhagic necrosis of transplanted tumors in mice and killed transformed cell lines in culture.1 These and other early studies showing anticancer potential led several laboratories to begin efforts to molecularly characterize TNF. Human TNF was purified and its complementary DNA cloned in 1984.2 TNF is initially synthesized as a preprotein of 233 amino acids, from which the N-terminal 76 amino acids are later removed. The 157 amino acid mature form of TNF exists as a 52-kd trimer of identical subunits.34


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Guidelines
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543