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Growth Factor Control of Type II Cell Apoptosis*

Randolph H. Hastings, MD, PhD; D. Summers-Torres; D. Burton; L. Deftos
Author and Funding Information

*From the Veterans Affairs San Diego Health Care System, San Diego, CA.

Correspondence to: Randolph H. Hastings, MD, PhD, Anesthesia Service, Veterans Affairs Medical Center, 3350 LaJolla Village Dr, San Diego, CA 92161-5085



Chest. 1999;116(suppl_1):68S-69S. doi:10.1378/chest.116.suppl_1.68S
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Extract

We have shown that parathyroid hormone-related protein (PTHrP) is an autocrine inhibitor of type II cell proliferation and apoptosis, that its expression falls in a reproducible fashion following acute lung injury, and that decreased levels of PTHrP are necessary for type II cell proliferation (Am J Crit Care Med 155:A583). PTHrP is an autocrine inhibitor of chondrocytes and cerebellar neurons (J Cell Biol 136:205; J Biol Chem 272:14404). This study investigated whether PTHrP inhibited apoptosis in type II cells.


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