have shown that parathyroid hormone-related protein (PTHrP) is an
autocrine inhibitor of type II cell proliferation and apoptosis, that
its expression falls in a reproducible fashion following acute lung
injury, and that decreased levels of PTHrP are necessary for type II
cell proliferation (Am J Crit Care Med 155:A583). PTHrP is an
autocrine inhibitor of chondrocytes and cerebellar neurons (J Cell
Biol 136:205; J Biol Chem 272:14404). This study investigated
whether PTHrP inhibited apoptosis in type II cells.