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Surfactant Protein C Promoter-Driven Expression of T1-Alpha Induces Lung Inflammation*

C.E. Girod, MD; D.H. Shin, MD, FCCP; M.W. Geraci, MD; H.B. Warren; L.G. Dobbs, MD, FCCP; B. Gao; J.S. Rainer; A.K. Bauer; M. Ikegami; J.M. Shannon, PhD; Y.E. Miller, MD
Author and Funding Information

*From the Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Denver, CO.

Correspondence to: M.W. Geraci, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Denver, CO 80262



Chest. 1999;116(suppl_1):61S. doi:10.1378/chest.116.suppl_1.61S
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T1-alpha (TIA) is a cell membrane protein expressed with high specificity by the alveolar (primarily type I cell), choroid plexus, and ciliary (ocular) epithelia in the rat. In the lung, TIA undergoes upregulation prior to birth as well as in several models of lung injury. The unusual pattern of basal expression and upregulation with physiologically critical events supports an important function for TIA. Analysis of predicted protein structure suggests that TIA is a type Ia membrane glycoprotein, but no homologies or motifs provide clues to function.


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