(TIA) is a cell membrane protein expressed with high specificity by the
alveolar (primarily type I cell), choroid plexus, and ciliary (ocular)
epithelia in the rat. In the lung, TIA undergoes upregulation prior to
birth as well as in several models of lung injury. The unusual pattern
of basal expression and upregulation with physiologically critical
events supports an important function for TIA. Analysis of predicted
protein structure suggests that TIA is a type Ia membrane glycoprotein,
but no homologies or motifs provide clues to function.