0
Articles |

Regulation of Neutrophil Activation in Acute Lung Injury*

Gregory P. Downey, MD, FCCP; Qin Dong; Joshua Kruger, BSc; Shoukat Dedhar; Vera Cherapanov
Author and Funding Information

*From the Department of Medicine (Drs. Downey, Dong, Kruger, and Cherapanov), Division of Respirology, The University of Toronto, Toronto, Ontario, Canada; and the British Columbia Cancer Agency (Dr. Dedhar), Jack Bell Research Centre, Vancouver, British Columbia, Canada. Supported by operating grants from the Ontario Thoracic Society, the Medical Research Council of Canada, and the National Institutes of Health. Dr. Downey is the recipient of a Career Scientist Award from the Ontario Ministry of Health.

Correspondence to: Gregory P. Downey, MD, FCCP, Clinical Sciences Division, Room 6264 Medical Sciences Bldg, University of Toronto, 1 Kings College Circle, Toronto, Ontario, Canada, M5S 1A8; e-mail: gregory.downey@utoronto.ca



Chest. 1999;116(suppl_1):46S-54S. doi:10.1378/chest.116.suppl_1.46S
Text Size: A A A
Published online

Extract

The syndrome of acute lung injury, also known as the ARDS,1 is initiated by a variety of local or systemic insults leading to diffuse damage to the pulmonary parenchyma. The first clinically recognizable consequences of this injury are in large part attributable to an increase in the permeability of the alveolar-capillary membrane with subsequent pulmonary edema.2 The damage to the lung can be the result of direct (toxic) injury to lung parenchymal cells (primarily endothelial and epithelial cells) or indirectly as a consequence of activation of the acute inflammatory response leading to release of cytotoxic leukocyte-derived products, including reactive oxygen species, proteolytic enzymes, cationic proteins, growth factors, eicosanoids, and cytokines. It is important to recognize that even direct injury to the pulmonary parenchyma is frequently complicated by secondary inflammatory damage that is responsible for most of the physiologic abnormalities.3


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543