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Polymorphonuclear Leukocytes Released From the Bone Marrow and Acute Lung Injury*

Stephan F. van Eeden, MD; Yuko Kitagawa, MD; Yukio Sato, MD; James C. Hogg, MD
Author and Funding Information

*From the UBC, Pulmonary Research Laboratory, St. Paul’s Hospital, Vancouver, BC, Canada.

Correspondence to: Stephan F. van Eeden, MD, Pulmonary Research Laboratory, St Paul’s Hospital, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada; e-mail: svaneeden@prl.pulmonary.ubc.ca



Chest. 1999;116(suppl_1):43S-46S. doi:10.1378/chest.116.suppl_1.43S
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Extract

Polymorphonuclear leukocytes (PMNs) are essential for host defense, but they also mediate tissue injury and have been implicated in the pathogenesis of several important diseases, including those that may trigger acute lung injury and ARDS.12 In these conditions, activated PMNs accumulate in lung microvessels and cause endothelial damage, increased vascular permeability, and produce tissue injury.3 The PMNs that mediate these changes come from either those already in the vascular space where they either circulate or marginate along vessel walls, or those released from the bone marrow into the vascular space.4


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