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Alloreactive Th1 Cells Localize in Lung and Induce Acute Lung Injury*

Anne E. Dixon, MD; J. B. Mandac; P. J. Martin; D. K. Madtes, MD; R. C. Hackman; J. G. Clark, MD
Author and Funding Information

*From the Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA.

Correspondence to: Joan G. Clark, MD, Pulmonary and Critical Care Program, Fred Hutchinson Cancer Research Center, D3 190, 1100 Fairview Ave, Seattle, WA 98109-1024



Chest. 1999;116(suppl_1):36S-37S. doi:10.1378/chest.116.suppl_1.36S
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Extract

Acute lung injury is a common complication of bone marrow transplantation. Acute graft-vs-host disease (GVHD) is a major risk factor for this acute, noninfectious lung injury. Studies in murine models of GVHD and humans undergoing allogeneic marrow transplantation have implicated Th1-type responses in the generation of severe GVHD. We have previously described a murine model of acute lung injury induced by cloned alloreactive Th1 cells that recognize a polymorphic cell surface glycoprotein, Ly5 (CD45), expressed on hematopoietic cells.12 Two Ly5 alleles (Ly5a and Ly5b) have been described in mice. IV administered alloreactive cloned T cells specific for host Ly5 antigen cause a mononuclear cell pulmonary vasculitis and interstitial pneumonitis. In vitro activation of anti-Ly5a T cells causes similar injury in Ly5b animals, indicating that a lung-specific antigen is not required. However, T cells labeled in vitro with bromodeoxyuridine were visualized by immunohistochemistry in lung inflammatory foci 24 h after injection.


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