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HTI56, An Integral Apical Membrane Protein of the Human Alveolar Type I Cell, Is a Biochemical Marker of Acute Lung Injury*

V. Newman; R. Gonzalez; M. Matthay, MD, FCCP; L. Dobbs, MD, FCCP
Author and Funding Information

*From the Cardiovascular Research Institute, Departments of Pediatrics and Medicine, University of California, San Francisco, CA.

Correspondence to: Dr. V. Newman, University of California San Francisco, Cardiovascular Research Institute, San Francisco, CA 94143-0130.



Chest. 1999;116(suppl_1):35S-36S. doi:10.1378/chest.116.suppl_1.35S
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Extract

Although injury to the alveolar epithelial barrier is thought to be of central importance in the pathogenesis of acute lung injury, at the present time (to our knowledge), there are no established biochemical markers for alveolar epithelial injury in human disease. We hypothesized that cell-specific alveolar epithelial apical plasma membrane proteins might be useful biochemical markers for lung injury. This hypothesis has been validated in various models of rodent lung injury, in which the airspace liquid content of RT140, a rat type I cell integral membrane protein, correlated directly with the extent of epithelial injury assessed by morphologic criteria (Am J Physiol 1995; 268:L181–186, and 1997; 272:L631–638). We have now extended these studies to human acute lung injury.


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