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Neutrophil-Derived Heparin-binding Protein*: A Monocyte-Specific Chemoattractant That Induces Monocyte Migration into Rabbit Lungs In Vivo

Dennis E. Doherty, MD, FCCP; J. Nakano, MD, FCCP; K. Nakano
Author and Funding Information

*From the Division of Pulmonary and Critical Care Medicine, University of Kentucky Chandler Medical Center, Lexington Veterans Affairs Medical Center, Lexington, KY, and Department of Medicine National Jewish Medical and Research Center, Denver, CO.

Correspondence to: Dennis E. Doherty, MD, Division of Pulmonary and Critical Care Medicine, University of Kentucky Medical Center, 800 Rose St., MN 614, Lexington, KY 40536-0084



Chest. 1999;116(suppl_1):34S-35S. doi:10.1378/chest.116.suppl_1.34S-a
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Extract

During acute inflammatory processes in the lung, monocyte accumulation usually follows that of neutrophils. We and others have shown that in some systems, monocyte accumulation is a neutrophil-dependent event. One potential mechanism is that neutrophils generate monocyte chemoattractants.

Human heparin-binding protein (HBP) is a proteolytically inactive neutrophil elastase homologue with sequence identity to CAP37 and azurocidin. Activated neutrophils have been shown to secrete significant amounts of HBP. We have shown by immunohistochemistry that this cationic protein co-localizes with neutrophils in acute inflammatory lung lesions of patients with asthma and ARDS. We have also shown that human HBP, purified by ion exchange and molecular sieve chromatography (personal communication; Dr. Hans Flodgaard; Bagvaerd, Denmark), functions as a monocyte-specific chemoattractant in vitro.


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