0
Articles |

Cyclic Adenosine Monophosphate Protects Endothelial Barrier Function Independent of Inhibiting 20-kd Myosin Light Chain-Dependent Tension Development*

Alan B. Moy, MD, FCCP; James E. Bodmer; Ken Blackwell; Sandy Shasby; Anant Kamath; D. Michael Shasby, MD, FCCP
Author and Funding Information

*From the Department of Internal Medicine and the Department of Biomedical Engineering, University of Iowa College of Medicine, Iowa City, IA.

Correspondence to: Alan Moy, MD, University of Iowa College of Medicine, 200 Hawkins Dr., Iowa City, IA 52242-1081



Chest. 1999;116(suppl_1):33S. doi:10.1378/chest.116.suppl_1.33S
Text Size: A A A
Published online

Extract

We sought to directly test the hypothesis that cyclic adenosine monophosphate (cAMP) protects endothelial barrier function through inhibition of 20-kd myosin light chain (MLC20)-dependent tension development. We previously reported that thrombin and histamine initiate a disruption in transendothelial resistance, a dynamic and quantitative index of endothelial barrier function, across cultured human umbilical vein endothelial cells independent of tension development. However, the restoration of barrier function in response to thrombin was dependent on MLC20-dependent and independent pathways. Thus, cAMP could protect barrier function by accelerating restoration of barrier function through a MLC20-sensitive pathway. Alternatively, cAMP might act by preventing a MLC20-insensitive disruption of barrier function or by accelerating restoration of barrier function through a MLC20-insensitive pathway.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543