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Differential Regulation of Vascular Endothelial Growth Factor During Ventilated Pulmonary Ischemia*

Aimee Yu, MD; A. Alcasabas; G. Semenza, MD; P. Becker, MD
Author and Funding Information

*From the Johns Hopkins School of Medicine, Baltimore, MD.

Correspondence to: Aimee Yu, MD, Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224



Chest. 1999;116(suppl_1):32S. doi:10.1378/chest.116.suppl_1.32S
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Extract

Pulmonary vascular permeability increases during ventilated ischemia, before reperfusion, in isolated ferret lungs. The mechanism of this injury is not well understood, but it is likely to differ from other organs, as pulmonary ischemia is not necessarily synonymous with hypoxia if ventilation is maintained when blood flow is impaired.

Preliminary evidence from our laboratory demonstrates that vascular endothelial growth factor (VEGF), a potent mediator of increased vascular permeability, is upregulated during pulmonary ischemia. Interestingly, this VEGF induction is not oxygen dependent and occurs to the same degree in lungs ventilated with oxygen or nitrogen during 180 min of ischemia.


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