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Adenoviral-Mediated Overexpression of the NA,K-ATPase β1 Subunit Gene Increases Lung Edema Clearance and Improves Survival During Acute Hyperoxic Lung Injury in Rats*

Phillip Factor, DO, FCCP; Vidas Dumasius; Fernado Saldias, MD; Jacob I. Sznajder, MD, FCCP
Author and Funding Information

*From the Section of Pulmonary and Critical Care Medicine, Michael Reese Hospital, and University of Illinois at Chicago, Chicago, IL.

Correspondence to: Phillip Factor, DO, FCCP, Pulmonary and Critical Care Medicine, Michael Reese Hospital and Medical Center, 2929 S Ellis, 314 Kunstader, Chicago, IL 60616; e-mail: PFACT@AOL.COM



Chest. 1999;116(suppl_1):24S-25S. doi:10.1378/chest.116.suppl_1.24S
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Extract

Rats exposed to acute hyperoxia develop a lung injury characterized by pulmonary edema and decreased ability to clear lung liquid.12 Accumulating evidence indicates that active Na+ transport is an important contributor to lung edema clearance.5 In the alveolus, Na,K-adenosine triphosphatases (ATPases) have been shown to be responsible for active Na+ transport across the alveolar epithelium.,3,56 These pumps works in concert with other epithelial transport proteins, including water and apical Na+ channels, to generate a transepithelial Na+ gradient that causes the movement of water out of the alveolar airspace.,6


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