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Gelatinase B Deficiency Does Not Protect Against Lipopolysaccharide-Induced Acute Lung Injury*

Tomoko Betsuyaku, MD, PhD; J. Michael Shipley, PhD; Zhi Liu, PhD; Robert M. Senior, MD
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*From the Pulmonary and Critical Care Medicine Division, Washington University School of Medicine (Drs. Betsuyaku, Shipley, and Senior), St. Louis, MO, and the Department of Dermatology, Medical College of Wisconsin (Dr. Liu), Milwaukee, WI.

Correspondence to Tomoko Betsuyaku, MD, Pulmonary and Critical Care Medicine, Barnes Jewish Hospital, 216 S Kingshighway Blvd, St. Louis, MO 63110



Chest. 1999;116(suppl_1):17S-18S. doi:10.1378/chest.116.suppl_1.17S
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Polymorphonuclear leukocytes (PMNs) contain gelatinase B, a matrix metalloproteinase that is readily released from these cells upon stimulation with a variety of agents. Because gelatinase B degrades basement membrane components, and because inhibition of matrix metalloproteinase activity blunts PMN migration through basement membrane in vitro, gelatinase B may be required for PMN emigration in the lung and other tissues. High levels of gelatinase B have been reported in BAL fluid in ARDS patients, raising the possibility that gelatinase B contributes to the pathophysiology of ARDS.


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