0
Articles |

Hyaluronan Fragments Induce Plasminogen Activator Inhibitor-1 and Inhibit Urokinase Activity in Mouse Alveolar Macrophages*: A Potential Mechanism for Impaired Fibrinolytic Activity in Acute Lung Injury

M. R. Horton, MD; M. A. Olman, MD; P. W. Noble, MD
Author and Funding Information

*From the Divisions of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, University of Alabama, Birmingham, AL, and Yale University School of Medicine, New Haven, CT, and the VA-CT Healthcare System, West Haven, CT.

Correspondence to: Paul Noble, MD, Yale University School of Medicine, LCI 105, 333 Cedar St, PO Box 208057, New Haven, CT 06520-8057



Chest. 1999;116(suppl_1):17S. doi:10.1378/chest.116.suppl_1.17S
Text Size: A A A
Published online

Extract

Impaired fibrinolytic activity within the lung is an important component of acute lung injury. Recent evidence has suggested that the inability to resorb fibrin may contribute to increased lung fibrosis in animal models of acute lung injury. Overexpression of plasminogen activator inhibitor-1 (PAI-1) in transgenic mice resulted in increased lung collagen deposition following treatment with bleomycin.1

Macrophages are an important source of PAI-1 activity, but the mechanisms that regulate PAI-1 expression in alveolar macrophages are poorly understood. Turnover of the extracellular matrix has been shown to be an early event in acute lung injury. One component of the extracellular matrix that has been shown to be increased in animal models of acute lung injury and in patients with ARDS is the glycosaminoglycan hyaluronan (HA).


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
Guidelines
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543