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Extensive Mediastinal Lymphadenopathy in an Adult Immunocompetent Woman Caused by Mycobacterium avium Complex*

Ulf Greinert, MD; Sabine Rüsch-Gerdes, PhD; Ekkehard Vollmer, MD; Max Schlaak, MD
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*From the Department of Clinical Medicine (Drs. Schlaak and Greinert), the National Reference Center for Mycobacteria (Dr. Rüsch-Gerdes), and the Division of Clinical and Experimental Pathology (Dr. Vollmer), Research Center, Borstel, Germany.

Correspondence to: Ulf Greinert, MD, Department of Clinical Medicine, Parkallee 35, Research Center Borstel, D-23845 Borstel, Germany; e-mail: ugreinert@fz-borstel.de



Chest. 1999;116(6):1814-1816. doi:10.1378/chest.116.6.1814
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We report a case of extensive mediastinal lymphadenopathy in a 29-year-old immunocompetent woman, which was thought to be caused by Mycobacterium tuberculosis (MTB). Chest radiographs showed deterioration while the patient was receiving antituberculous medication for 8 months. After isolation of Mycobacterium avium complex (MAC) from a lymph node aspiration biopsy and switch to a MAC-specific therapeutic regimen, the lesion almost completely disappeared within 1 year. To our knowledge, this is the first report of an extensive mediastinal lymphadenopathy caused by MAC in an immunocompetent adult.

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