To the Editor:
In his editorial, “Insulin Without Injections???” (December
1998),1Dr. Misbin stated that type 1 diabetics would
still need a daily insulin injection to maintain basal levels;
therefore, optimism regarding the total elimination of injections was
not warranted. I am pleased to refer him and your readers to an article
by Edwards et al,2 which demonstrated inhaled insulin
activity for up to 96 h in rats. The hope of insulin without injections
is not a “pipe dream”; there is actually cause for substantial
optimism in this area. There are at least three US companies that have
research agreements with major pharmaceutical houses for inhaled
insulin. Some are already doing phase 3 clinical studies. These
companies are on the web: durapharm. com, aradigm.com, and inhale.com.
Correspondence to: Mark Mecikalski, MD, FCCP, 7580 N Calle
sin Desengano, Tucson, AZ, 85718; e-mail: DAB7580@aol.com
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