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Communications to the Editor |

Insulin by Inhalation? FREE TO VIEW

Mark Mecikalski, MD, FCCP
Chest. 1999;116(2):581. doi:10.1378/chest.116.2.581
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Published online

To the Editor:

In his editorial, “Insulin Without Injections???” (December 1998),1Dr. Misbin stated that type 1 diabetics would still need a daily insulin injection to maintain basal levels; therefore, optimism regarding the total elimination of injections was not warranted. I am pleased to refer him and your readers to an article by Edwards et al,2 which demonstrated inhaled insulin activity for up to 96 h in rats. The hope of insulin without injections is not a “pipe dream”; there is actually cause for substantial optimism in this area. There are at least three US companies that have research agreements with major pharmaceutical houses for inhaled insulin. Some are already doing phase 3 clinical studies. These companies are on the web: durapharm. com, aradigm.com, and inhale.com.

Correspondence to: Mark Mecikalski, MD, FCCP, 7580 N Calle sin Desengano, Tucson, AZ, 85718; e-mail: DAB7580@aol.com

References

Misbin, RI (1998) Insulin Without Injections??? What have you been puffing?Chest114,1513. [PubMed] [CrossRef]
 
Edwards, DA, Hanes, J, Caponetti, G, et al Large porous particles for pulmonary drug delivery.Science1997;276,1868-1871. [PubMed]
 

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References

Misbin, RI (1998) Insulin Without Injections??? What have you been puffing?Chest114,1513. [PubMed] [CrossRef]
 
Edwards, DA, Hanes, J, Caponetti, G, et al Large porous particles for pulmonary drug delivery.Science1997;276,1868-1871. [PubMed]
 
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