Wegener’s granulomatosis (WG) and α1-antitrypsin
(α1-AT)-deficiency emphysema are both uncommon disorders.
A relationship may exist between these diseases involving the
proteinase and antiproteinase balance in the lung. A case is presented
of WG and α1-AT-deficiency emphysema occurring in the
same patient. Previous studies concerning the correlation between
abnormal α1-AT alleles and WG are discussed. Potential
mechanisms for the relationship and recommendations for screening are