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Wegener’s Granulomatosis and α1-Antitrypsin-Deficiency Emphysema*: Proteinase-Related Diseases

V. Theodore Barnett, MD, FCCP; Marin Sekosan, MD; Abid Khurshid, MD, FCCP
Author and Funding Information

*From the Section of Respiratory and Critical Care Medicine, Department of Medicine (Drs. Barnett and Khurshid), and Department of Pathology (Dr. Sekosan), University of Illinois at Chicago, Chicago, IL.

Correspondence to: V. Theodore Barnett, MD, FCCP, Section of Respiratory and Critical Care, Department of Medicine (MC 787), University of Illinois, 840 S Wood St, Chicago, IL 60612; e-mail: vtbarnet@uic.edu



Chest. 1999;116(1):253-255. doi:10.1378/chest.116.1.253
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Wegener’s granulomatosis (WG) and α1-antitrypsin (α1-AT)-deficiency emphysema are both uncommon disorders. A relationship may exist between these diseases involving the proteinase and antiproteinase balance in the lung. A case is presented of WG and α1-AT-deficiency emphysema occurring in the same patient. Previous studies concerning the correlation between abnormal α1-AT alleles and WG are discussed. Potential mechanisms for the relationship and recommendations for screening are given.

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