Clinically, auricular chondritis (55%), ocular symptoms
(eg, conjunctivitis, [epi]scleritis, and uveitis[
32%]), nasal chondritis (30%), and arthritis (20%) are the most
frequent findings at presentation. Laryngotracheal involvement
(hoarseness, aphonia, tracheal tenderness, and stenosis with cough,
dyspnea, or stridor) occurs less frequently, although it may
represent a critical and potentially lethal organic system involvement.
Flow-volume analysis in patients with largyngotracheal involvement
typically allows objectivation of central airway stenosis and may be
helpful in follow-up evaluations: typically, a flattened inspiratory
loop is observed in case of extrathoracic airway stenosis, a
flattened expiratory loop is observed in case of intrathoracic
stenosis. In case of fixed severe stenosis, both inspiratory an
expiratory loops may be flattened.