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Pulmonary Manifestations of POEMS Syndrome*: Case Report and Literature Review

Babak Mokhlesi, MD; Manu Jain, MD
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*From the Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Medical School, Chicago, IL.



Chest. 1999;115(6):1740-1742. doi:10.1378/chest.115.6.1740
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Phrenic nerve paresis is an unusual complication of POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein spike and skin changes) syndrome. In this report, we describe a case of POEMS syndrome in which a 56-year-old woman presented with dyspnea and ventilatory failure due to bilateral phrenic nerve paralysis. To our knowledge, only one other case of phrenic neuropathy in POEMS syndrome has been reported.


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