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Positive Antineutrophil Cytoplasmic Antibodies- Associated Vasculitis Presenting With Hemoptysis and a Mediastinal Mass*

Herma H. Fidder, MD; Sara Apter, MD; Pnina Langevitz, MD; Sarit Aviel-Ronen, MD; Ilan Bank, MD; Avi Livneh, MD
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*From the Departments of Medicine, Imaging, and Pathology, Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel-Hashomer, Israel.

Correspondence to: Herma H. Fidder, MD, Department of Medicine F, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel; e-mail: gastro@netvision.net.il



Chest. 1999;115(5):1473-1475. doi:10.1378/chest.115.5.1473
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A patient with end-stage renal failure, due to IgA nephropathy, was found to have a mediastinal mass. Biopsy specimen of the mass showed a necrotizing vasculitis. Antineutrophil antibodies to myeloperoxidase were strongly positive. To our knowledge, no case of a mediastinal mass due vasculitis has been reported in the literature, and our observation should lead to broadening of the spectrum of clinical manifestations of vasculitis.

Abbreviations: ANCA = antineutrophil cytoplasmic antibodies; MPA = microscopic polyangiitis; PAN = polyarteritis nodosa; p-ANCA = perinuclear antineutrophil cytoplasmic antibodies

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