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Respiratory Distress Due to Minocycline-Induced Pulmonary Lupus*

Christodoulos S. Christodoulou, MD; Patricia Emmanuel, MD; Rachel A. Ray, MD; Robert A. Good, MD, PhD, DSc; Bruce M. Schnapf, DO, FCCP; Gail D. Cawkwell, MD, PhD
Author and Funding Information

*From the Department of Pediatrics (Drs. Christodoulou, Good, and Cawkwell), Division of Allergy/Immunology, University of South Florida/All Children’s Hospital, St. Petersburg, FL; Department of Pediatrics (Drs. Emmanuel and Ray); and Department of Pediatrics, Division of Pulmonary Medicine (Dr. Schnapf), University of South Florida, Tampa, FL.

Correspondence to: Christodoulos S. Christodoulou, MD, All Children’s Hospital, 801 Sixth St S, Box 9350, St. Petersburg, FL 33701



Chest. 1999;115(5):1471-1473. doi:10.1378/chest.115.5.1471
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Minocycline, a semisynthetic tetracycline, is often used to treat acne and rheumatoid arthritis. It has been considered an unlikely drug to be associated with systemic lupus erythematosus; however, many cases of drug-induced lupus related to minocycline have been reported. Some of those reports included pulmonary lupus, but none of the patients described developed respiratory distress. We describe a patient treated with minocycline for 2 years who presented with progressive dyspnea, severe hypoxia, and pulmonary infiltrates necessitating hospitalization and oxygen supplementation.

Abbreviations: ANA = antinuclear antibodies; ANCA = antineutrophil cytoplasmic autoantibodies; Nl = normal level; SLE = systemic lupus erythematosus

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