0
Selected Reports |

Photopheresis in the Treatment of Refractory Bronchiolitis Obliterans Complicating Lung Transplantation*

Adrian R. O’Hagan, MD; Paul C. Stillwell, MD, FCCP; Alejandro Arroliga, MD, FCCP; Anna Koo, MD
Author and Funding Information

*From the St. Louis Children’s Hospital (Dr. O’Hagan), St. Louis, MO; the San Diego Children’s Hospital (Dr. Stillwell), San Diego, CA; and the Cleveland Clinic Foundation (Drs. Arroliga and Koo), Cleveland, OH.

Correspondence to: Paul C. Stillwell, MD, FCCP, San Diego Children’s Hospital, Pediatric Pulmonary Suite 205, 3030 Children’s Way, San Diego, CA 92123-4282; e-mail: pstillwell@chsd.org



Chest. 1999;115(5):1459-1462. doi:10.1378/chest.115.5.1459
Text Size: A A A
Published online

Photopheresis has been successfully used to treat heart allograft rejection and has had some initial success in the treatment of bronchiolitis obliterans (BO) following lung transplantation. This report describes five patients treated with photopheresis after the failure of augmented immunosuppression for BO. Four patients had a temporary stabilization of their airflow obstruction, and minimal side effects of the procedure were noted, although there were consequences from additional augmented immunosuppression (principally sepsis). Photopheresis may provide a safe modality for the treatment of BO that is unresponsive to standard and augmented immunosuppression.

Abbreviations: ATG = antithymocyte globulin; BO = bronchi-olitis obliterans; CSA = cyclosporine; FK506 = tacrolimus; MTX =methotrexate; OKT3 = monomurine anti-C3 antibody


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543