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Pulmonary Langerhans’ Cell Histiocytosis*: Radiologic Resolution Following Smoking Cessation

Nesrin Mogulkoc, MD; Ali Veral, MD; Paul W. Bishop, MB, BCh; Ülkü Bayindir, MD; C. Anthony C. Pickering, MD; Jim J. Egan, MD
Author and Funding Information

*From Ege University Hospital, (Drs. Mogulkoc, Veral, and Bayindir), Izmir, Turkey; and Wythenshawe Hospital, (Drs. Bishop, Pickering, and Egan), Manchester, UK.

Correspondence to: Nesrin Mogulkoc, MD, North West Lung Research Center, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester, M23 9LT, United Kingdom; e-mail: 100046.1102@compuserve.com



Chest. 1999;115(5):1452-1455. doi:10.1378/chest.115.5.1452
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We describe two patients with histologically proven pulmonary Langerhans’ cell histiocytosis in whom radiologic improvement occurred following smoking cessation. The patients had 23- and 25-pack-year smoking histories, respectively. High-resolution CT revealed multiple small nodules, located predominantly in the upper and middle lung fields. There was a close temporal relationship between smoking cessation and radiologic improvement.

Abbreviations: BLPs = bombesin-like peptides; CD10/NEP = CD10/neutral endopeptidase; CRP = C-reactive protein; Dlco = diffusing capacity of the lung for carbon monoxide; HRCT = high-resolution CT; LCH = Langerhans’ cell histiocytosis; TLC = total lung capacity

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