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Nitric Oxide in Adult Lung Disease*

C. Michael Hart, MD, FCCP
Author and Funding Information

*From Indiana University and Roudebush Veterans Administration Medical Center, Indianapolis, IN. Supported by grants from the Veterans Administration Research Service, the National Institutes of Health, and the American Diabetes Association.

Correspondence to: Mike Hart, MD, Indiana University, 1001 W 10th St, WD-OPW-425, Indianapolis, IN 46202-2879; e-mail: cmhart@iupui.edu



Chest. 1999;115(5):1407-1417. doi:10.1378/chest.115.5.1407
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Advances in the understanding of nitric oxide as a biological mediator and a therapeutic tool continue to accumulate at a rapid rate. This review provides an update on recent developments pertinent to the role of nitric oxide in adult lung disease. After a brief review of basic nitric oxide biochemistry and physiology, the evidence supporting the role of nitric oxide in the regulation of vascular and airway tone in the normal lung is considered. Clinical studies addressing the pathophysiological role of nitric oxide in pulmonary hypertension, airway disease, and lung injury are reviewed, and the application of inhaled nitric oxide therapy is discussed.

Abbreviations: cGMP = cyclic 3′,5′-guanosine monophosphate; NANC = nonadrenergic noncholinergic; NO2 = nitrogen dioxide; NOS = nitric oxide synthase; ONOO = peroxynitrite; ppb = parts per billion; V̇/Q̇ = ventilation/perfusion

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