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Emerging Therapies for Cystic Fibrosis Lung Disease*

Bruce K. Rubin, MD, FCCP
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*From the Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC.



Chest. 1999;115(4):1120-1126. doi:10.1378/chest.115.4.1120
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For many years, the treatment of cystic fibrosis (CF) pulmonary disease focused on the control of airway infection, secretion mobilization, and reduction of airway inflammation. Advances on these fronts have greatly decreased disease-related morbidity and mortality over the past 20 years.1,,2 Since the CF gene was identified and cloned in 1987, the research emphasis has been on developing methods to correct the basic ion transport defects, with the hope of controlling and, eventually, curing this disease. This update reviews both new information related to the traditional approaches of CF pulmonary complication management, as well as recent basic science research that holds the promise of novel therapies for this disease.

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    Print ISSN: 0012-3692
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