Study objectives: To investigate in older persons
whether diabetes mellitus is an independent risk factor for congestive
heart failure (CHF).
Design: A prospective study was
performed in 2,737 older persons investigating the incidence of new CHF
in persons with and without diabetes mellitus.
Setting: A long-term health-care facility.
Patients: Eight hundred sixty-five men and 1,872 women,
with a mean age of 81 ± 9 years.
results: At 43-month follow-up, new CHF developed in 272 of 690
persons (39%) with diabetes mellitus and in 467 of 2,047 persons
(23%) without diabetes mellitus (p < 0.0001). Cox regression
analysis showed that age (p = 0.0001, risk ratio = 1.048),
hypertension (p = 0.0001, risk ratio = 2.524), coronary artery
disease (p = 0.0001, risk ratio = 4.008), male gender
(p = 0.0001, risk ratio = 1.399), and diabetes mellitus
(p = 0.0003, risk ratio = 1.337) were significantly positively
associated with the time to the development of CHF.
Conclusions: Older persons with diabetes mellitus had a 1.3
times higher chance of developing CHF than those without diabetes
mellitus after controlling the confounding effects of other prognostic
Abbreviations: CAD = coronary artery
disease; CHF = congestive heart failure