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A Reversible Cause of Hypercapnic Respiratory Failure*: Lower Motor Neuronopathy Associated With Renal Cell Carcinoma

Daniel Forman, DO; Alexander D. Rae-Grant, MD; Stephen C. Matchett, MD; Jay S. Cowen, MD
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*From the Department of Medicine (Dr. Forman), Divisions of Neurology (Dr. Rae-Grant) and Pulmonary and Critical Care Medicine (Drs. Matchett and Cowen), Lehigh Valley Hospital, Allentown, PA.



Chest. 1999;115(3):899-901. doi:10.1378/chest.115.3.899
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We describe a unique case of a patient with a reversible paraneoplastic motor neuronopathy who presented with hypercapnic respiratory failure. The patient developed progressive respiratory and limb muscle weakness until treated with removal of a renal cell carcinoma, which was followed by a complete resolution of neuromuscular symptoms. The literature of paraneoplastic motor neuronopathies is reviewed, specifically in reference to respiratory failure.

Abbreviations: EMG = electromyography; LMN = lower motor neuron; MND = motor neuron disease; UMN = upper motor neuron


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