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Editorials |

The Emerging Role of Leukotriene Antagonists in Asthma Therapy

Brian J. Lipworth, MD
Author and Funding Information

Affiliations: Dundee, Scotland, UK 
 ,  Professor of Allergy and Respiratory Medicine, Department of Clinical Pharmacology and Therapeutics and Department of Respiratory Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK.

Affiliations: Dundee, Scotland, UK 
 ,  Professor of Allergy and Respiratory Medicine, Department of Clinical Pharmacology and Therapeutics and Department of Respiratory Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK.



Chest. 1999;115(2):313-316. doi:10.1378/chest.115.2.313
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Extract

The drug therapy of asthma has remained essentially unchanged over the past 3 decades, comprising use of glucocorticoids,β 2-agonists, and theophyllines. The antileukotrienes and particularly the leukotriene antagonists represent an important new class of drug therapy for asthma. At present, the use of the 5-lipoxygenase inhibitor zileuton is somewhat limited due to its four-times-daily dosing regimen and the need to monitor biochemical liver function tests. The advantages of the available leukotriene antagonists are the use of once-daily (montelukast) or twice-daily (zafirlukast) dosing in terms of improved compliance, as well as there being no need to routinely monitor liver function. The leukotriene antagonists seem to be effective over a wide range of asthma disease severity, although their precise role in asthma management guidelines has yet to be established due to the relatively small published database on long-term clinical efficacy.


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  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543