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Clinical Investigations: COPD |

Body Composition Analysis by Dual Energy X-ray Absorptiometry and Exercise Performance in Underweight Patients With COPD*

Masanori Yoshikawa, MD; Takahiro Yoneda, MD; Atsushi Kobayashi, MD; Akihiro Fu, MD; Hideaki Takenaka, MD; Nobuhiro Narita, MD; Kunimoto Nezu, MD, FCCP
Author and Funding Information

*From the Second Department of Internal Medicine and Department of Surgery III, Nara Medical University, Nara, Japan.



Chest. 1999;115(2):371-375. doi:10.1378/chest.115.2.371
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Study objectives: The aim of this study was to examine the effect of body composition on maximal exercise performance in patients with COPD.

Methods: The study was carried out on 27 patients with COPD and was confirmed by pulmonary function testing. Body composition was measured by dual energy x-ray absorptiometry (DXA). Exercise performance was conducted on a cycle ergometer and was measured as maximal work rate (WRmax) and maximal oxygen uptake (V̇o2max). Bone mineral content (BMC), lean mass (LEAN), and fat mass (FAT) were assessed by DXA and were expressed as a percentage of ideal body weight, BMC, LEAN, and FAT.

Results: LEAN% correlated significantly with V̇o2max (r = 0.66, p = 0.0002) and WRmax (r = 0.70, p < 0.0001). No significant correlation was found between FAT% and exercise performance. By stepwise regression analysis, variables significantly contributing to WRmax and V̇o2max were LEAN% and the maximal voluntary ventilation. Total variance explained in these models was 81% for WRmax and 82% for V̇o2max.

Conclusion: Lean mass was an important determinant of maximal exercise performance in patients with COPD.

Abbreviations: BMC = bone mineral content; BMC% = percentage of BMC; Dlco = diffusing capacity of the lung for carbon monoxide; DXA = dual energy x-ray absorptiometry; FAT = fat mass; FAT% = percentage of FAT; FFM = fat-free mass; %IBW = percentage of ideal body weight; LEAN = lean mass; LEAN% = percentage of LEAN; MVV = maximal voluntary ventilation; RV = residual volume; TLC = total lung capacity; V̇o2max = maximal oxygen uptake; WRmax = maximal work rate

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