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Two Cases of Repeatedly Recurrent Atypical Thymoma*

Kazuya Kondo, MD; Syouji Sakiyama, MD; Keiji Takahashi, MD; Tadashi Uyama, MD, FCCP; Yasumasa Monden, MD, FCCP; Yukio Shimosato, MD, PhD
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*From the Second Department of Surgery (Drs. Kondo, Sakiyama, Takahashi, and Uyama), School of Medicine, the University of Tokushima, Kuramoto-cho, Tokushima, and the Department of Pathology (Dr. Shimosato), Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.



Chest. 1999;115(1):282-285. doi:10.1378/chest.115.1.282
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Two cases of repeatedly recurrent thymoma with myasthenia gravis are detailed here. A 41-year-old woman had 5 recurrent thymomas, including local recurrences and lumbar and lung metastases; she was alive at the time of this writing, which was 22 years after her first surgery. A 36-year-old man had 3 recurrent thymomas, including local recurrence, dissemination, and lung metastasis; he was alive at the time of this writing, which was 16 years after his first surgery. Both recurrent lesions were diagnosed as “atypical thymoma” with moderate nuclear atypia. The patients with atypical thymoma must be followed up carefully due to a possible recurrence. Surgical treatment with chemoradiotherapy can lengthen their survival.

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