0
Editorials |

Antimicrobial Therapy of Ventilator-Associated Pneumonia : How To Select an Appropriate Drug Regimen

Marin H. Kollef, MD, FCCP
Author and Funding Information

Affiliations: St. Louis, MO 
 ,  Associate Professor of Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine; Director, Medical ICU; and Director, Respiratory Care Services, Barnes-Jewish Hospital, St. Louis, MO.

Correspondence to: Marin H. Kollef, MD, FCCP, Pulmonary and Critical Care Division, Washington University School of Medicine, Box 8052, 660 S Euclid Ave, St. Louis, MO 63110; e-mail: mkollef@pulmonary.wustl.edu



Chest. 1999;115(1):8-11. doi:10.1378/chest.115.1.8
Text Size: A A A
Published online

Extract

Ventilator-associated pneumonia (VAP) refers to nosocomial pneumonia developing in a patient receiving mechanical ventilation. VAP is recognized as being one of the leading causes of death from hospital-acquired infections in the ICU setting.1,,2 The estimated prevalence of VAP ranges from 10 to 65% with case fatality rates of 13 to 55%.3,,4 Additionally, several clinical studies have demonstrated an attributable mortality associated with VAP that is independent of patients’ underlying diagnoses and severity of illness at the time of ICU admission.5,,6 The occurrence of VAP also increases the costs associated with hospitalization. Several economic analyses estimate the excess medical costs attributed to an episode of VAP to be > $5,000 with prolongation of the hospital stay from 6 to > 30 days.7,,8,,9 Recently, the importance of providing early effective antimicrobial therapy for patients with VAP has been highlighted by several clinical investigations.10,,11,,12,,13


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Guidelines
Feverish illness in children: assessment and initial management in children younger than 5 years.
National Collaborating Centre for Women's and Children's Health | 8/28/2009
Blepharitis.
American Academy of Ophthalmology | 6/5/2009
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543