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Editorials |

Circulating Natriuretic Peptides : A Biologic Marker of Tissue Injury?

Israel Rubinstein, MD; FCCP Dennis Hong, MD, FCCP
Author and Funding Information

Affiliations: Chicago, IL 
 ,  Dr. Rubinstein is an Associate Professor and Dr. Hong is an Assistant Professor at the University of Illinois at Chicago.

Correspondence to: Israel Rubinstein, MD, Department of Medicine (M/C 787), University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612-7323; e-mail: IRubinst@uic.edu



Chest. 1999;115(1):7-8. doi:10.1378/chest.115.1.7
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Extract

The family of natriuretic peptides comprises five structurally-related 22-53-amino acid peptides, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), two C-type natriuretic peptides (CNP), and dendroaspis natriuretic peptide (DNP).1 They express broad and disparate effects in the cardiovascular system, including natriuresis, diuresis, vasodilation, and inhibition of the renin-angiotensin system, sympathetic outflow, and vascular smooth muscle and endothelial cell proliferation.1


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