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Therapeutic Digoxin Level in Chylous Drainage With no Detectable Plasma Digoxin Level FREE TO VIEW

Mark D. Taylor; Song Soon Kim; Lydia J. Vaias
Author and Funding Information

From the Long Beach Veterans Administration Hospital, Department of Surgery, University of California in Irvine School of Medicine

Song Soon Kim, PharmD, Long Beach Veterans Administration Hospital, Department of Surgery, 5901 E. 7th Street, Long Beach, CA 90822

1998 by the American College of Chest Physicians

Chest. 1998;114(5):1482-1484. doi:10.1378/chest.114.5.1482
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A patient receiving digoxin for long-standing congestive heart failure developed a chylothorax following removal of an infected aortic graft. Drainage of the chylothorax resulted in plasma digoxin concentrations which were near zero while the digoxin levels in the chylous drainage fluid were therapeutic. The sequestration of even low lipid-soluble drugs, such as digoxin, in chyle should be recognized to prevent subtherapeutic plasma levels in patients undergoing chylothorax drainage.




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