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Prognostic Significance of Lewis y Antigen in Resected Stage I and II Non-small Cell Lung Cancer

Syed A. Mehdi; Arthur H. Tatum; Nancy B. Newman; Anna Imperato; John Daucher; Leslie J. Kohman; Stephen L. Graziano
Author and Funding Information

Affiliations: From the Department of Medicine, Veterans Affairs Medical Center and State University of New York-Health Science Center, Syracuse, NY 13210,  From the Department of Pathology, Veterans Affairs Medical Center and State University of New York-Health Science Center, Syracuse, NY 13210,  From the Department of Surgery, Veterans Affairs Medical Center and State University of New York-Health Science Center, Syracuse, NY 13210

Stephen L. Graziano, MD, Veterans Affairs Medical Center, 800 Irving Avenue, Syracuse, NY 13210


1998 by the American College of Chest Physicians


Chest. 1998;114(5):1309-1315. doi:10.1378/chest.114.5.1309
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Abstract

Background: The role of Lewis y (Ley) antigen expression has been studied extensively in predicting the outcome of various malignancies. We evaluated the expression of Ley and its relationship to survival, disease-free survival and other clinicopathologic variables in patients with stage I and II non-small cell lung cancer (NSCLC).

Objective: To investigate the prognostic significance of Ley antigen expression in a large group of well characterized patients with resected stage I and II NSCLC.

Patients: Two hundred and sixty patients with surgically resected stage I (n = 193) and II (n = 67) NSCLC with at least 5-year follow-up were identified.

Results: The median survival for patients with negative expression of Ley (< 50% of cells that were positive) was 46 months, whereas for those with positive expression of Ley (≥ 50%), the median survival was 54 months (p = 0.99). The disease-free survival for patients with Ley(−) expression was 39 months and 34 months for patients with Ley(+) expression (p = 0.3).

Conclusions: We found no relationship between loss of blood group antigen A and expression of Ley. No statistically significant difference was found in survival between positive and negative expression of Ley antigen in patients with resected stage I and II NSCLC.


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