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Integrating Patient Preferences Into Health Outcomes Assessment : The Multiattribute Asthma Symptom Utility Index FREE TO VIEW

Dennis A. Revicki; Nancy Kline Leidy; Fiona Brennan-Diemer; Sonja Sorensen; Alkis Togias
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Affiliations: From the MEDTAP International, Inc, Bethesda, MD,  From the Johns Hopkins Asthma and Allergy Center, Baltimore, MD.

Dennis Revicki, PhD, Center for Health Outcomes Research, MEDTAP International, Inc, 7101 Wisconsin Ave, Suite 600, Bethesda, MD 20814, e-mail: Revicki@Medtap.com

1998 by the American College of Chest Physicians

Chest. 1998;114(4):998-1007. doi:10.1378/chest.114.4.998
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Study objective: To develop and evaluate a brief, easy-to-administer symptom assessment scale for use as a preference-based outcome measure in clinical trials and cost-effectiveness studies in asthma.

Design: Cross-sectional survey with 2-week reproducibility assessment.

Setting: Ambulatory care: university asthma and allergy center.

Participants: One hundred sixty-one adults with asthma, 59% female, mean age 35 ± 11 years. Mean FEV1 percent predicted was 86 ± 17%.

Interventions: The 11-item Asthma Symptom Utility Index (ASUI).

Measurements and results: Mean ASUI score for this sample was 0.71 ± 0.23, with a range from 0.02 to 1.0. The ASUI was reproducible (intraclass correlation coefficient = 0.74) and able to distinguish patients known to differ on disease severity according to clinician ratings (p < 0.001) and by an asthma disease severity scale score (p < 0.001). The instrument was also significantly correlated with FEV1 percent predicted (r = 0.27, p < 0.001), the Asthma Quality of Life Questionnaire (r = 0.77, p < 0.001), and the Health Utilities Index Mark 2 (r = 0.36, p < 0.001).

Conclusion: The results of this study support the reliability and validity of the ASUI, suggesting it will be a useful, complementary patient outcome measure for clinical trials and cost-effectiveness studies comparing treatment alternatives for persons with asthma.




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