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Hypersensitivity Pneumonitis Due to Humidifier Disease : Seek and Ye Shall Find

Roy Patterson; Nili Mazur; Mary Roberts; Dante Scarpelli; Ronald Semerdjian; Kathleen E. Harris
Author and Funding Information

Affiliations: From the Department of Medicine, Northwestern University Medical School, Chicago, IL,  From the Department of Pathology, Northwestern University Medical School, Chicago, IL,  From Evanston Hospital, Evanston, IL

Roy Patterson, MD, FCCP, Division of Allergy-Immunology, Northwestern University Medical School, 303 E Chicago Ave, Chicago, IL 60611


1998 by the American College of Chest Physicians


Chest. 1998;114(3):931-933. doi:10.1378/chest.114.3.931
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Abstract

Study Objectives: This study reports a classic case of hypersensitivity pneumonitis (HP) with classic histologic changes in lung tissue and the research used to identify the causative antigens.

Design: A patient with clinical, radiographic, pulmonary function abnormalities and a lung biopsy consistent with HP had no identifiable antigen exposure.

Setting: Evaluation of the patient's activities provided no suggestion of antigen exposure. Her home was evaluated. It was found that her humidifier ran continually without being cleaned but water was added periodically.

Measurements: Serologic analysis demonstrated precipitating antibodies against her humidifier water and ten antigens in the hypersensitivity lung disease serologic panel.

Conclusion: Removal of the humidifier, cleaning of the house, and a course of prednisone resulted in the return of the patient to a normal state.


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