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Gemfibrozil-Warfarin Drug Interaction Resulting in Profound Hypoprothrombinemia

Joseph P. Rindone; Hai-Chi Keng
Author and Funding Information

From the Veterans Affairs Medical Center, Prescott, Ariz.

Joseph P. Rindone, PharmD, VA Medical Center (119), Prescoth, AZ 86313


1998 by the American College of Chest Physicians


Chest. 1998;114(2):641-642. doi:10.1378/chest.114.2.641
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Abstract

The following describes a patient on a stable regimen of warfarin who developed severe hypoprothrombinemia and bleeding 4 weeks after starting gemfibrozil. Despite a warning by the manufacturer, only one report of this interaction has been published in the literature. This interaction may be overlooked by clinicians, which may result in a serious bleeding risk for patients on warfarin.


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