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The Therapeutic Potential of Nitric Oxide in Lung Transplantation

Keith C. Meyer; Robert B. Love; Jerry J. Zimmerman
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Affiliations: From the Section of Pulmonary and Critical Care Medicine, Departments of Medicine, University of Wisconsin Medical School, Madison,  From the Section of Surgery, University of Wisconsin Medical School, Madison,  From the Section of Pediatrics, University of Wisconsin Medical School, Madison

Affiliations: From the Section of Pulmonary and Critical Care Medicine, Departments of Medicine, University of Wisconsin Medical School, Madison,  From the Section of Surgery, University of Wisconsin Medical School, Madison,  From the Section of Pediatrics, University of Wisconsin Medical School, Madison

Affiliations: From the Section of Pulmonary and Critical Care Medicine, Departments of Medicine, University of Wisconsin Medical School, Madison,  From the Section of Surgery, University of Wisconsin Medical School, Madison,  From the Section of Pediatrics, University of Wisconsin Medical School, Madison


1998 by the American College of Chest Physicians


Chest. 1998;113(5):1360-1371. doi:10.1378/chest.113.5.1360
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Abstract

Endogenously produced oxides of nitrogen appear to play important roles in tissue and organ homeostasis. Endogenous production of nitric oxide, which can be altered in response to various stimuli, can modulate vascular tone, oxyradical cascades, cell adhesion, and other aspects of inflammation. Because exogenously administered (inhaled) nitric oxide can mediate pulmonary vasodilatation and improve pulmonary function in some patients with lung injury, treatment of lung allograft recipients with inhaled nitric oxide may ameliorate ischemia-reperfusion injury, thereby improving perioperative pulmonary function and diminishing ventilatory support requirements. This review examines the biology of nitric oxide and present data that support its potential therapeutic effects for lung transplant recipients.


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