0
Articles |

Systemic Inflammation Present in Patients Undergoing CABG Without Extracorporeal Circulation

Erik Fransen; Jos Maessen; Mieke Dentener; Nicole Senden; Gijs Geskes; Wim Buurman
Author and Funding Information

Affiliations: From the Department of Cardiopulmonary Surgery, University Hospital Maastricht, Maastricht, the Netherlands,  From the Department of Pulmonology, University Hospital Maastricht, Maastricht, the Netherlands,  From the Department of Surgery, University Hospital Maastricht, Maastricht, the Netherlands

Affiliations: From the Department of Cardiopulmonary Surgery, University Hospital Maastricht, Maastricht, the Netherlands,  From the Department of Pulmonology, University Hospital Maastricht, Maastricht, the Netherlands,  From the Department of Surgery, University Hospital Maastricht, Maastricht, the Netherlands

Affiliations: From the Department of Cardiopulmonary Surgery, University Hospital Maastricht, Maastricht, the Netherlands,  From the Department of Pulmonology, University Hospital Maastricht, Maastricht, the Netherlands,  From the Department of Surgery, University Hospital Maastricht, Maastricht, the Netherlands


1998 by the American College of Chest Physicians


Chest. 1998;113(5):1290-1295. doi:10.1378/chest.113.5.1290
Text Size: A A A
Published online

Abstract

Study objectives: This study was conducted to evaluate to what extent the cardiopulmonary bypass (CPB) procedure in patients undergoing coronary artery bypass grafting (CABG) contributes to the systemic inflammatory response. Therefore, we measured bactericidal permeability increasing protein (BPI) as an indicator of neutrophil activation, interleukin 6 as inducer of the acute phase response, and lipopolysaccharide binding protein and C-reactive protein as parameters of the acute phase response in patients undergoing CABG either with or without the use of CPB.

Design: Prospective study.

Setting: Cardiopulmonary surgery department in a university hospital.

Patients: Sixteen patients undergoing elective CABG were included. Eight patients underwent surgery with CPB, and eight patients underwent surgery without CPB (non-CPB).

Interventions: In the CPB group, blood samples were taken upon induction of anesthesia, at the start of aortic cross-clamping, at aortic unclamping, and 0.5, 4, 8, and 18 h thereafter. In the non-CPB group, blood samples were taken upon induction of anesthesia, and 0.5, 4, 8, and 18 h after completion of the bypass graft anastomoses.

Measurements and results: BPI release from neutrophil granules markedly increased during surgery in CPB patients but not in non-CPB patients. The increase in acute phase reactants, however, was the same in both patient groups.

Conclusions: These data indicate that the acute phase response in CABG patients, which has historically been ascribed to the CPB procedure, is predominantly caused by the surgical procedure per se. Early neutrophil activation, however, is seen only when extracorporeal circulation is used.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543