Articles |

The Relation Between Multiple Sleep Latency Test Findings and the Frequency of Apneic Events in REM and Non-REM Sleep FREE TO VIEW

Ronald D. Chervin; Michael S. Aldrich
Author and Funding Information

From the Department of Neurology and Sleep Disorders Center, University of Michigan Medical Center, Ann Arbor

1998 by the American College of Chest Physicians

Chest. 1998;113(4):980-984. doi:10.1378/chest.113.4.980
Text Size: A A A
Published online


Study objectives: A recent study of 34 patients with mild obstructive sleep apnea syndrome (OSAS) suggested that the number of apneas and hypopneas per hour of sleep (apnea/hypopnea index [AHI]) may show a stronger correlation with sleepiness, as measured by the Multiple Sleep Latency Test (MSLT), when calculated for rapid eye movement (REM) sleep alone (AHIR) as opposed to the entire night. We sought to reexamine this possibility in a larger group of similar patients and in patients who had a wider range of OSAS severity.

Design: Retrospective and observational.

Setting: A large, accredited, academic sleep disorders center where a database of sleep study results is maintained.

Patients: We studied 1,146 persons who had polysomnography and MSLTs for clinical indications.

Results: In linear regression models, the AHI explained 11.0% of the variance in MSLT results, AHIN (AHI during non-REM sleep) explained 10.8%, and AHIR explained only 6.0% (p≤0.0001 for each). Among subjects with AHI <10, the AHI explained 3.1% of the variance (p=0.0012), the AHIN 2.3% (p=0.0049), and the AHIR 0.2% (p=0.40). Among all subjects, the ratio AHIR/AHIN had no influence on the overall relationship between AHI and sleepiness (p=0.23).

Conclusions: We conclude that apneic events during REM and non-REM sleep probably contribute equally to sleepiness as measured by the MSLT.




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543