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Strategies and Options for Minimizing Resistance Emergence in Pulmonary Infections

Sebastian G. B. Amyes
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From the Department of Medical Microbiology, The Medical School, University of Edinburgh, Scotland


1998 by the American College of Chest Physicians


Chest. 1998;113(3_Supplement):228S-232S. doi:10.1378/chest.113.3_Supplement.228S
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Abstract

The early-onset hospital pulmonary Gram-negative infections may respond to ciprofloxacin and co-amoxiclav without significant resistance development. Penicillin-resistant Streptococcus pneumoniae may be treated with macrolides, fluoroquinolones, and glycopeptides. The late-onset hospital pathogens all seem to have developed resistance to cephalosporins, so greater reliance is now made on the fluoroquinolones and carbapenems when aminoglycoside therapy is considered undesirable.


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