0
Articles |

Short-term Growth in Asthmatic Children Using Fluticasone Propionate

Martin J. Visser; Wim M.C. van Aalderen; Barbara M. Elliott; Roelof J. Odink; Paul L.P. Brand
Author and Funding Information

Affiliations: From the Department of Pediatric Pulmonology, Beatrix Children's Hospital, University Hospital Groningen, The Netherlands,  From the Pediatric Endocrinology, Beatrix Children's Hospital, University Hospital Groningen, The Netherlands

Affiliations: From the Department of Pediatric Pulmonology, Beatrix Children's Hospital, University Hospital Groningen, The Netherlands,  From the Pediatric Endocrinology, Beatrix Children's Hospital, University Hospital Groningen, The Netherlands


1998 by the American College of Chest Physicians


Chest. 1998;113(3):584-586. doi:10.1378/chest.113.3.584
Text Size: A A A
Published online

Abstract

Background: Inhaled corticosteroids may reduce short-term growth velocity in asthmatic children and knemometry is the most sensitive tool to detect this short-term growth suppression.

Study objective: To compare lower leg growth velocity, as measured by knemometry, in asthmatic children during and after treatment with inhaled fluticasone propionate (FP), 100 µg twice daily.

Design: Nonrandomized open trial.

Setting: University hospital, outpatient clinic for pediatric pulmonology.

Patients: Twenty-one asthmatic children (13 boys), aged 6 to 10 years.

Interventions: Inhalation of FP from a dry powder inhaler, 100 µg, twice daily for 6 weeks, followed by 2 weeks during which only an inhaled β2-agonist was used on demand (washout). During treatment and washout periods, patients were seen every 2 weeks at the same time of day.

Measurements and results: Lower leg growth velocity measured by knemometry during FP treatment was not significantly different from that during washout (p=0.33, one-way analysis of variance).

Conclusions: No significant suppression of lower leg growth velocity was found in prepubertal asthmatic children using FP, 100 µg, by dry powder inhaler twice daily for 6 weeks.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543