0
Articles |

Bronchoalveolar Carcinoma : Histopathologic Study of Evolution in a Series of 105 Surgically Treated Patients

Pascal Dumont; Bernard Gasser; Clothilde Rougé; Gilbert Massard; Jean-Marie Wihlm
Author and Funding Information

Affiliations: From the Department of Thoracic Surgery, Hôpital Trousseau, CHU de Tours, France,  From the Department of Pathology, Hôpital Civil, CHU de Strasbourg, France,  From the Department of Thoracic Surgery, Hôpital Civil, CHU de Strasbourg, France

Affiliations: From the Department of Thoracic Surgery, Hôpital Trousseau, CHU de Tours, France,  From the Department of Pathology, Hôpital Civil, CHU de Strasbourg, France,  From the Department of Thoracic Surgery, Hôpital Civil, CHU de Strasbourg, France

Affiliations: From the Department of Thoracic Surgery, Hôpital Trousseau, CHU de Tours, France,  From the Department of Pathology, Hôpital Civil, CHU de Strasbourg, France,  From the Department of Thoracic Surgery, Hôpital Civil, CHU de Strasbourg, France


1998 by the American College of Chest Physicians


Chest. 1998;113(2):391-395. doi:10.1378/chest.113.2.391
Text Size: A A A
Published online

Abstract

Study objective: The clinical characteristics, histopathologic condition, and outcome of bronchoalveolar carcinoma (BAC) were studied to detect possible prognostic indicators.

Design: A retrospective review was conducted of 97 patients who had a curative resection for BAC between 1975 and 1993.

Patients: There were 83 men and 14 women with a mean age of 59 years (30 to 75 years).

Interventions: Resection comprised lobectomy in 84 cases (87%), bilobectomy, pneumonectomy, and a wedge excision.

Results: Sixty-two percent of patients were asymptomatic. The radiographic pattern was a solitary nodule in 85% of patients and lobar pneumonitis or diffuse infiltrate in 15%. In 12% of patients, the solitary lesion had been stable for period of 2 to 7 years before diagnosis. The TNM staging of the disease included 71 patients with stage I, 14 with stage II, and 12 with stage IIIA. Review of the gross pathologic features revealed well-circumscribed tumors in 88% of patients and diffuse or multifocal tumors in 12%. Mucinous differentiation was present in 43% of patients, vascular invasion in 22%, and aerogenous spread in 49%. Overall survival was 89% at 1 year, 76% at 2 years, 48% at 5 years, and 39% at 10 years. The survival curves according to histologic features showed a statistically significant difference between diffuse lesions and nodular lesions, between lesions with and without aerogenous spread (diffuse lesions excluded), and between lesions with and without vascular invasion.

Conclusions: The natural history of BAC is especially influenced by its nodular or diffuse nature, vascular invasion, and aerogenous spread.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543