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Acute Oxygen Supplementation Does Not Relieve the Impairment of Respiratory Muscle Strength in Hypoxemic COPD

Raffaele Antonelli Incalzi; Leonello Fuso; Teresa Ricci; Sandra Sammarro; Antonio Dicorcia; Aldo Albano; Riccardo Pistelli
Author and Funding Information

Affiliations: From the Department of Geriatrics, Catholic University, Rome,  From the Department of Respiratory Physiology, Catholic University, Rome,  From the Department of Respiratoiy Physiology, Ospedale "Casa Sollievo della Sofferenza," S. Giovanni Rotondo (FG), Italy

Affiliations: From the Department of Geriatrics, Catholic University, Rome,  From the Department of Respiratory Physiology, Catholic University, Rome,  From the Department of Respiratoiy Physiology, Ospedale "Casa Sollievo della Sofferenza," S. Giovanni Rotondo (FG), Italy

Affiliations: From the Department of Geriatrics, Catholic University, Rome,  From the Department of Respiratory Physiology, Catholic University, Rome,  From the Department of Respiratoiy Physiology, Ospedale "Casa Sollievo della Sofferenza," S. Giovanni Rotondo (FG), Italy


1998 by the American College of Chest Physicians


Chest. 1998;113(2):334-339. doi:10.1378/chest.113.2.334
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Abstract

Study objectives: To verify whether hypoxemia affects respiratory muscle strength in the absence of malnutrition and whether such effect, if present, is reversible with an acute oxygen supplementation.

Design: Case series analysis, before-after trial.

Setting: Outpatient pneumology departments of two university hospitals.

Patients: One hundred twenty patients affected by COPD in stable conditions having actual to ideal body weight ratio of ≥90%.

Measurements and results: Maximal inspiratory pressure (MIP) was measured at functional residual capacity level in the whole sample of subjects and during oxygen supplementation in 58 patients having a PaO2 ≤60 mm Hg when breathing in room air. Predictors of MIP were assessed by a multivariate analysis. MIP values before and after oxygen supplementation were compared by a paired t test. MIP was independently correlated with FVC (p<0.001), PaO2 (p<0.01), and age (p<0.01). In the subgroup of hypoxemic patients, MIP values did not change significantly after oxygen supplementation (3.08±1.74 vs 3.03±1.91 kPa, t=0.43, not significant).

Conclusions: Hypoxemia is an important negative correlate of MIP even in well-nourished COPD patients. Its effect is not reversible with an acute oxygen supplementation.


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