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Considerations in Optimizing Radiation Therapy for Non-small Cell Lung Cancer

Joel S. Greenberger; Sanjeev Bahri; James Jett; Chandra Belani; Andre Kalend; Michael Epperly
Author and Funding Information

From the Department of Radiation Oncology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute


1998 by the American College of Chest Physicians


Chest. 1998;113(1_Supplement):46S-52S. doi:10.1378/chest.113.1_Supplement.46S
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Abstract

Irradiation therapy for lung cancer is mostly restricted to conventional methods. To improve therapeutic ratio, we have combined a treatment planning and a gene therapy approach. Three-dimensional conformal radiotherapy is described as carried out by methods of gene therapy for radiation protection using the manganese-superoxide-dismutase transgene delivered by inhalation gene transfer. These methods may improve therapeutic outcomes in lung cancer.


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