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5-HT1Dβ Receptor Mediates the Supersensitivity of Isolated Coronary Artery to Serotonin in Variant Angina

Tatsuro Ishida; Ken-ichi Hirata; Tsuyoshi Sakoda; Kenji Kanazawa; Seinosuke Kawashima; Hozuka Akita; Mitsuhiro Yokoyama
Author and Funding Information

From the First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan


1998 by the American College of Chest Physicians


Chest. 1998;113(1):243-244. doi:10.1378/chest.113.1.243
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Abstract

Although serotonin (5-hydroxytryptamine; 5-HT) is used for provocation of coronary spasm, 5-HT receptor subtypes in spastic coronary arteries remain undetermined. We demonstrated the supersensitivity of isolated coronary artery to ergonovine, 5-HT, and sumatriptan, a 5-HT1D receptor agonist, in a patient with variant angina. Furthermore, we detected gene expression of 5-HT1Dβ and 5-HT2A receptors in spastic coronary artery using RNase protection assay. These findings suggest that the leftward shift of the dose-response curve for 5-HT, which plays an important role in the pathogenesis of coronary spasm, is mediated by activation of 5-HT1Dβ receptor.


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