0
Articles |

Vasculitis and Bronchiectasis in a Patient With Antibodies to Bactericidal/Permeability-Increasing Protein and α1-Antitrypsin Deficiency

Ravi Mahadeva; Ming Hui Zhao; Susan Stewart; Nathaniel Cary; Christopher Flower; Martin Lockwood; John Shneerson
Author and Funding Information

Affiliations: From the Department of Respiratory Medicine, Addenbrooke's Hospital, Cambridge, UK.,  From the Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.,  From the Department of Pathology, Papworth Hospital, Cambridge, UK.,  From the Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.

Affiliations: From the Department of Respiratory Medicine, Addenbrooke's Hospital, Cambridge, UK.,  From the Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.,  From the Department of Pathology, Papworth Hospital, Cambridge, UK.,  From the Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.

Affiliations: From the Department of Respiratory Medicine, Addenbrooke's Hospital, Cambridge, UK.,  From the Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.,  From the Department of Pathology, Papworth Hospital, Cambridge, UK.,  From the Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.

Affiliations: From the Department of Respiratory Medicine, Addenbrooke's Hospital, Cambridge, UK.,  From the Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.,  From the Department of Pathology, Papworth Hospital, Cambridge, UK.,  From the Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.


1997 by the American College of Chest Physicians


Chest. 1997;112(6):1699-1701. doi:10.1378/chest.112.6.1699
Text Size: A A A
Published online

Abstract

A patient with α1-antitrypsin deficiency is reported herein; this subject developed aggressive bronchial disease and recurrent cutaneous vasculitis after pulmonary infection with Pseudomonas aeruginosa. Autoantibodies to neutrophil cytoplasmic antigens were detected, which produced granular cytoplasmic staining by indirect immunofluorescence with specificity for a newly characterized antigen: bactericidal/permeability-increasing protein (BPI). The bronchial disease and vasculitis improved, and the IgA anti-BPI titer fell after antipseudomonal treatment. This raises the possibility that anti-BPI antibodies contributed to both the bronchial disease and vasculitis.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543