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End-Stage Cystic Fibrosis : Improved Diabetes Control 2 Years After Successful Isolated Pancreatic Cell and Double-Lung Transplantation

Jean-Marie Tschopp; Martin H. Brutsche; Jean-Georges Frey; Anastase Spiliopoulos; Laurent Nicod; Thierry Rochat; Philippe Morel
Author and Funding Information

Affiliations: From the Centre Valaisan de Pneumologie, Montana, Switzerland,  From the Departments of Thoracic Surgery and Medecine, Hôpital Cantonal, Universitaire, Genève, Switzerland

Affiliations: From the Centre Valaisan de Pneumologie, Montana, Switzerland,  From the Departments of Thoracic Surgery and Medecine, Hôpital Cantonal, Universitaire, Genève, Switzerland


1997 by the American College of Chest Physicians


Chest. 1997;112(6):1685-1687. doi:10.1378/chest.112.6.1685
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Abstract

Over a period of years, insulin-dependent diabetes and respiratory insufficiency developed in a 35-year-old patient with end-stage cystic fibrosis. After waiting more than 4 years while receiving maintenance treatment with continuous liquid O2 and nasal ventilation, the patient underwent double-lung and pancreatic islet cell transplantation. Subsequently, the patient has enjoyed a normal life with full employment and much better control of his diabetes. Pancreatic islet cell transplantation is a simple and innocuous technique easily added to the end of lung transplantation. These new pancreatic cells, although locally injected, are still secreting more than 2 years later as assessed by repeated C-peptide measurements.


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