0
Articles |

Verbal Memory Impairment in COPD : Its Mechanisms and Clinical Relevance

Raffaele Antonelli Incalzi; PierUgo Carhonin; Antonella Gemma; Oliviero Capparella; Camillo Marra; Leonello Fuso
Author and Funding Information

Affiliations: From the Department of Geriatrics, Catholic University of the Sacred Heart, Rome,  From the Teaching Nursing Home Cittadella della Carità, Taranto, Italy,  From the Department of Neurology, Catholic University of the Sacred Heart, Rome,  From the Department of Pneumology, Catholic University of the Sacred Heart, Rome

Affiliations: From the Department of Geriatrics, Catholic University of the Sacred Heart, Rome,  From the Teaching Nursing Home Cittadella della Carità, Taranto, Italy,  From the Department of Neurology, Catholic University of the Sacred Heart, Rome,  From the Department of Pneumology, Catholic University of the Sacred Heart, Rome

Affiliations: From the Department of Geriatrics, Catholic University of the Sacred Heart, Rome,  From the Teaching Nursing Home Cittadella della Carità, Taranto, Italy,  From the Department of Neurology, Catholic University of the Sacred Heart, Rome,  From the Department of Pneumology, Catholic University of the Sacred Heart, Rome

Affiliations: From the Department of Geriatrics, Catholic University of the Sacred Heart, Rome,  From the Teaching Nursing Home Cittadella della Carità, Taranto, Italy,  From the Department of Neurology, Catholic University of the Sacred Heart, Rome,  From the Department of Pneumology, Catholic University of the Sacred Heart, Rome


1997 by the American College of Chest Physicians


Chest. 1997;112(6):1506-1513. doi:10.1378/chest.112.6.1506
Text Size: A A A
Published online

Abstract

Study objectives: Identification of mechanisms accounting for verbal memory impairment in patients with severe COPD; assessing the relationship between verbal memory and the overall cognitive performance; verifying if verbal memory impairment affects medication adherence.

Design: Case-comparison study.

Setting: Outpatient Departments of Pneumology and Neurology, Day Hospital of General Surgery.

Patients: Forty-two COPD ambulatory patients, age 70±9.7 years, with hypoxemia and hypercarbia (group A); 27 normal subjects of comparable age and educational level (group B); 31 patients with Alzheimer's disease (group C); and 26 older normal subjects (group D).

Measurements and results: The overall cognitive function and verbal memory were evaluated by the Mental Deterioration Battery and 14 indexes of verbal memory. Defective retrieval and recognition mechanisms distinguished group A from group B. According to discriminant analysis, verbal memory profile of COPD patients was group specific in 38.1% of cases and conformed to that of group B, C, and D in 19%, 16.7%, and 26.2% of cases, respectively. In COPD patients, both immediate and delayed recall, the strongest determinants of the discriminant function, were significantly correlated with the overall cognitive performance (rho=0.64, p=0.001; rho=0.61, p=0.001, respectively). Poor adherence to medication regimen was significantly associated with abnormal delayed recall score (82.3% vs 36% in subjects with normal delayed recall, p<0.008).

Conclusions: Decline of verbal memory parallels that of the overall cognitive function in COPD patients and is due to the impairment of both active recall and passive recognition of learned material. It could be an important determinant of the level of medication adherence.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543